I use two hosts and one Supermicro Server as storage system with open-e v7 for management. There are only SSD on this storage system.
iSCSI target tuning on open-e side to match the vmware iSCSI settings is also done.
I know the "Best Practices Guideline" and setup wasn't a issue at all. I already set up Jumbo Frames, Multipathing with two vmkernels and two subnets, Round Robin with IOPS=1 and ofc 10GB ethernet between host and storage.
I'm just not sure what's the way to go since there are 3 Options in my Oppinion:
1) one LUN - one target: creare multiple datastorages inside vSphere on this LUN
2) multiple LUNs according to the needed datastorage no. and connect all of them with one iSCSI target
3) multiple LUNs according to the needed datastorage no. and one iSCSI target for each LUN