As per my understanding , jumbo frames should be enabled end to end to avoid packet drops also it causes bottlenecks
consider you have a server and end point. Server has MTU 1500 and all other devices (switched till end point has MTU 9000) , when a packet sent from endpoint with size greater than 1500 to server , since server supports only MTU 1500, the packet gets dropped vice versa won't be an issue.
so , its generally suggested to have jumbo frames enabled end to end so that there wont be any packet drops.