Have same BSOD problem with same HD 6450 on i5-2500 and Intel Q67 with ESXi 6.0 while trying to make it work under windows 10 VM.
I had this card working on ESXi 5.0 and Xeon 1230 with Windows 7 for a while, but after processor upgrade (to make use of vPro KVM) with ESXi upgrade it just gives VIDEO_TDR_FAILURE inside VM every time it try to activate the screen. Is 6450 some particular model to avoid? Or all Radeons is broken completely in newer ESXi? Will NVIDIA work?
I tried to disable audio, internal graphic. No other devices attached to slots.
Thanks for sharing!